Med Hypotheses. 2016 Mar;88:74-8. doi: 10.1016/j.mehy.2016.01.015. Epub 2016 Feb 2.
Autism: Will vitamin D supplementation during pregnancy and early childhood reduce the recurrence rate of autism in newborn siblings?
Stubbs G1, Henley K2, Green J2.
Vitamin D deficiency is widespread in the world including the vulnerable group of pregnant women. Vitamin D deficiency during pregnancy is hypothesized to contribute to the cause of autism. Further, it is hypothesized that vitamin D supplementation during pregnancy and early childhood will reduce the recurrence rate of autism in newborn siblings.
To investigate the hypothesis an open label prospective study was performed prescribingvitamin D during pregnancy to mothers of children with autism at a dose of 5000IU/day. The newborn siblings were at high risk for the recurrence of autism. The newborn infants were also prescribed vitamin D, 1000IU/day to their third birthday. The newborn siblings were followed for three years and during that time, were assessed for autism on two separate occasions: at 18months and 36months of age. The results were compared to the reported recurrence rates in siblings of autistic children in the literature.
The final outcome was 1 out of 19 (5%) developed autism in contrast to the recurrence rate of approximately 20% in the literature. We did not have a control group, nor was there blinding.
The results are promising, however, this is a preliminary study with very small numbers and was uncontrolled. Further study with larger numbers is indicated. The ethics of prescribing a low dosage of vitamin D such as 400IU D3/day to a control group of mothers in comparison to a large dosesuch as 5000IU D3/day are problematic in our opinion.
Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
PMID: 26880644 DOI: 10.1016/j.mehy.2016.01.015
Jeff T. Bowles
Jeff T Bowles: Being the author of the best-selling book on Vitamin D3 in the world, and given the topic of the book was the miraculous results of my one-year experiment of taking HIGH DOSES of vitamin D3, this puts me in the unique position of being the sounding board for many hundreds if not a few thousands of others who have embarked on their own high-dose vitamin D3 experiment. Nobody on planet earth has this amount of unusual and exciting knowledge, and I will be sharing it with you in this series of 100 short articles describing a disease and some sort of amazing result achieved with high-dose D3 therapy.
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