BMJ Open Diabetes Res Care. 2016 Feb 10;4(1):e000148. doi: 10.1136/bmjdrc-2015-000148. eCollection 2016.
Vitamin D for the treatment of painful diabetic neuropathy.
Basit A1, Basit KA2, Fawwad A1, Shaheen F2, Fatima N2, Petropoulos IN3, Alam U4, Malik RA5.
To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy.
A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks.
143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001).
Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.
TRIAL REGISTRATION NUMBER:
Neuropathy Complications; Neuropathy and Clinical Diabetes; Pain; Vitamin D
Jeff T. Bowles
Jeff T Bowles: Being the author of the best-selling book on Vitamin D3 in the world, and given the topic of the book was the miraculous results of my one-year experiment of taking HIGH DOSES of vitamin D3, this puts me in the unique position of being the sounding board for many hundreds if not a few thousands of others who have embarked on their own high-dose vitamin D3 experiment. Nobody on planet earth has this amount of unusual and exciting knowledge, and I will be sharing it with you in this series of 100 short articles describing a disease and some sort of amazing result achieved with high-dose D3 therapy.
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